Literature & References



Weidmann A et al., Pre-vention of lens epithelial cell growth in vitro using mibefradil-containing PLGA micro particles. The Open Ophtalmology Journal, 2008, 2: 112-118.

Ceriotti L et al., Online monitoring of BALB/3T3 metabolism and adhesion with multiparametric chip-based system. Analytical Biochemistry, 2007, 371 (1): 92-104.

Thedinga E et al., In vitro system for prediction of hepatotoxic effects in primary hepatocytes. ALTEX, 2007, 24 (1):22-34.

Thedinga E et al., On-line monitoring of cell metabolism for studying pharmaco-dynamic effects. Toxicology and Applied Pharmacology, 2007, 220: 33-44.

Ceriotti L et al., Real-time assessment of cytotoxicity by impedance measurement on a 96-well plate. Sensors and Actuators B: Chemical, 2006, 123 (2): 769-778.

Kubisch R et al., Characterization of eucaryotic cells as the sensitive layer of cell based cytotoxity sensors Procedia Chemistry 1, 2009, 730 733

Dransfeld Chr-L et al., Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3, Clinical Epigenetics 2010

Drechsler S, Andrä J, Online monitoring of metabolism and morphology of peptide-treated neuroblastoma cancer cells and keratinocytes, Journal of Bioenergetics and Biomembranes, 2011, Vol. 43/3, 275-285

Mariani V et al., Online monitoring of cell metabolism to asses the toxicity of nanoparticles: The case of cobalt ferrite, Nanotoxicology, 2011; Early Online, 1-16


Pre-clinical drug evaluation

Hille A et al., [N,N'-Bis-(salicylidene)-1,2-phenylene-diamine]metal complexes with cell death promotion properties. Journal of Bio-logical Inorganic Chemistry, 2009, 14 (5): 711-25.

Harlos M et al., Synthesis, biological activity and structure -activity relation-ships for potent cytotoxic rhodium(III) polypyridyl com-plexes. Journal of Medicinal Chemistry, 2008, 51: 3924-3933.



Abarzua S et al., Online Monitoring of Cellular Metabolism in the MCF7-Carcinoma Cell Line Treated with Phytoestrogen Extracts. Anticancer Research, 2010,  30: 1587- 1592

Dransfeld et al., SIRT3SNPs validation in 640 individuals, functional analyses and new insights into  SIRT3 stability. International Journal of Oncology, 2010, 36: 955-960

Mestres P and Morguet A, The Bionas technology for anticancer drug screening. Expert Opinion on Drug Discovery, 2009, 4 (7): 785-797.

Schatzschneider U et al., Cellular uptake, cytotoxicity and metabolic profiling of human cancer cells treated with ruthenium(II) polypyridyl complexes [Ru(bpy)2(N--N)]C12 with N--N=bpy, phen, dpq, dppz and dppn. ChemMedChem, 2008, 3:1104-1109.

Mestres-Ventura P et al., Application of silicon sensor technologies to tumor tissue in vitro: detection of metabolic correlates of chemosensitivity. Methods in Molecular Medicine, 2005, 111: 109-25.

Rubbiani R et al., Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with 2 multiple antitumor properties, J. Med. Chem. 2010

Bieda R et al., Antileukemic activity abd cellular effects of rhodium (III) crown thiaether complexes, Biometals, 2011 Jan 28

Geldmacher Y et al., Cellular selectivity and biological impact of cytotoxic rhodium(III) and iridium(III) complexes containing methyl-substituted phenantroline ligands, ChemMedChem, 2011 Mar 7

Alborzinia H, Real-time monitoring of cis-platin induced cell death, PLoS ONE 6(5): e19714. doi:10. 1371/journal.pone.001974 2011


Stem cells & Regeneration

Furlani D et al., A transformed cell population derived from cultured mesenchymal stem cells has no functional effect after transplantation into the injured heart. Cell Trans-plantation, 2009, 18: 319-331.

Rebl H et al., Time-dependent metabolic activity and adhesion of human osteoblast-like cells on sensor chips with a plasma polymer nanolayer, Int J Artif Organs , 2010; 33 (10)

Gaebel R et al., Cell Origin of Human Mesenchymal Stem Cells Determines a Different Healing Performance in Cardiac Regeneration PLoS One. 2011 Feb 10;6(2):e15652.




Ortinau 2010a, Label-free cell-based on-line monitoring of cells in the focus of pharmacological in vitro studies

Drechsler 2010a, Glycolysis or mitochondrial respiration? Influence of culture medium components on cell metabolism

Ortinau 2010b, Cell-based on-line monitoring of suspension cells in the focus of in vitro immunotoxicity studies

Ortinau 2010c, Real-time label-free monitoring of bioenergetics and cell impedance for long and short-term in vitro assays

Stuetz 2009a, Optimization of culture & measurement conditions for improved stability & sensitivity of cell physiology monitoring systems for toxicology applications

Alborzinia 2008, Effects of metal organic compounds on cell metabolism

Alborzinia 2007, Assessment of cellular metabolism and adhesion properties in response to apple extract

Jehle 2007b, Online monitoring of suspension cells in the focus of in vitro immunotoxicity-studies

Mestres 2006a, A new method to assess drug sensitivity on breast tumor acute slices preparation

Thedinga 2006a, In vitro detection of early signals of hepatotoxic effects

Weidmann 2006, Influence of the T-Type calcium channel blocker Mebefradil into signalling pathways in human lens epithelial cells

Thedinga 2004b, New automated cell based analyzing system for reduction of animal tests


Pre-clinical drug evaluation

Seeland 2010-10-29, Identification of P-Glycoprotein Substrates by Real-Time Monitoring of Living Cells

Harlos 2009, Effects of synthesized cytotoxic compounds on the metabolic activity of different tumor cells

Gatfield 2008, Integrating cell-impedance technology to characterize GPCR signalling in recombinant and non-recombinant cells

Thedinga 2004a, New automated cell based analyszing System for pre-clinical drug profiling



Abarzua 2008, Online monitoring of cellular metabolism for studying anticarcinogenic effects of Linum Phytoestrogen extracts in the human mammalian carcinoma cell line MCF7

Morguet 2008, The impact of p53 status on cellular sensitivity to 5 fluorouracil: mulit-parametric biosensor study

Morguet 2007 , Effects of Enzastaurin and Alimta on cancer cells and tumour tissue using the Bionas 2500 analyzing system a new silicon sensor-chip technology

Mestres 2006a, A new method to assess drug sensitivity on breast tumor acute slices preparation

Mestres 2006b, Applications of Silicon-Sensor-Chip Apparatus to Determine Cell and Tumour Chemo-sensitivity ex vivo


Stem cells & Regeneration

Furlani 2009a, Abnormal Rat Mesenchymal Stem Cells Do Not Improve the Cardiac Function of the Infarcted Heart

Gaebel 2009, Comparation of cardiac regenerative capacity of human mesenchymal stem cells from different sources

Niendorf 2009, Determination of the viability and activity of bone cells within a three dimensional scaffold matrix

Jesswein 2009, Time dependent adhesion of vital human osteoblasts on positively charged plasma polymer coated surfaces

Thedinga 2008, A novel cell based Analysis system for continuous determination of cell physiology


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